The aim of the present study was to develop chronomodulated drug delivery by using the principles of compression coat. Compression coated tablets of lercanidipine were prepared by direct compression method using chitosan. Tablets were evaluated for their physicochemical properties and in vitro drug release studies. Research is based on chronopharmacological phenomena and this demonstrates that the time of administration is a possible factor in variation of the pharmacokinetics of a drug. the coating thickness delays the drug release and prevents the drug release from the core by acting as a shield.
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